Akuammigine shows clear sympatholytic activity and antagonizes the effect of adrenaline on the heart, vessels and regulatory centre of the circulation system. Akuammidine has hypotensive, skeletal muscle relaxant and local analgesic activities. It acts selectively as a sympatholytic, unaccompanied by parasympatholytic effects. It inhibits the irritability of the sympathetic nervous system and opposes akuammine. Pseudo-akuammigine acts as an indirect reversible and competitive parasympathomimetic. In low doses it excites and in high doses it inhibits the central nervous system, respiration, contraction of the skeletal muscles and contraction of the smooth muscles. It increases hexobarbital-induced sleeping time and has local analgesic, anti-inflammatory, cholinesterase-inhibiting and hypotensive activities.