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The root of Synaptolepis kirkii `uvuma-omhlope' contains neurotrophins.
What are neurotrophins? : Neurotrophins are a family of molecules that encourage survival of nervous tissue. A molecule, usually a protein, that will facilitate the growth or repair of nerve cells. A protein, such as nerve growth factor, that promotes nerve cell growth and survival. Pharmacological effects : See `Kirkinine, a New Daphnane Orthoester with Potent Neurotrophic Activity from Synaptolepis kirkii' by authors He W; Cik M; Lesage A; Linden IVD; Kimpe ND; Appendino G; Bracke J; Mathenge SG; Mudida FP; Leysen JE; Puyvelde LV in the Journal of Natural Products, 63(9): pp. 1185-1192, 2000 ISSN: 0163-3864.
Abstract : The bioassay-guided fraction of a dichloromethane extract from the roots of Synaptolepis kirkii using neuronal viability as a model allowed the isolation of the new daphnane orthoester kirkinine (1a) as a powerful neurotrophic constituent.
Bioorg Med Chem. 2002 Oct;10(10):3245-55. Neurotrophic and antileukemic daphnane diterpenoids from Synaptolepis kirkii.Abstract : Biological assay guided fractionation of a dichloromethane extract of Synaptolepis kirkii led to the isolation of four new and five known daphnane-type diterpene orthoesters, whose structure was established by spectroscopic data. Full spectroscopic data of the new and known natural products are reported here for the first time. Pronounced neurotrophic and substantial antileukaemia activities of these compounds were found in in-vitro assays.
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